Index Terms: Asymptomatic, canine distemper, diagnosis, dogs. Amostra vacinal do vírus da cinomose canina em células VERO foi utilizada como controle. Canine distemper virus infection and secondary Bordetella bronchiseptica Palavras-chave: cães, vírus da cinomose canina, Bordetella bronchiseptica.

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Vaccine samples were kindly supplied 1. The mortality rate of the virus largely depends on the immune status of the infected dogs. This problem is even greater within areas such as Arizona, owing to the vast amount of rural land.

This article is about a disease generally affecting animals in the order Carnivora. In dogs, vanina of distemper vary widely from no signs, to mild respiratory signs indistinguishable from kennel coughto severe pneumonia with vomiting, bloody diarrhea, and death.

In Brazil at least two studies Bentubo et al.

Distemper Canino

An additional test to confirm distemper is a brush border slide of the bladder transitional epithelium of the inside lining from the bladder, stained with Diff-Quik. Areas distempe consolidation, and other large irregular shaped, greenish-grey, slightly depressed areas were seen, principally at the border of some pulmonary lobes. These affected teeth tend to erode quickly. Canine distemper CDone of the most fatal diseases in puppies, remains an important viral disease in the veterinary field.

Archived from the original on 18 January PCR reactions were set up cznina an isolated room, and gloves, face masks, and barrier tips were used during all experiments. Pathogenicity of morbilliviruses for terrestrial carnivores. The virus then enters the blood stream and infects the respiratorygastrointestinalurogenitalepithelial, and central nervous systemsand optic nerves.

Retrieved from ” https: Canine distemper virus tends to orient its infection towards the lymphoidepithelialand nervous tissues.

Canine distemper virus infection with secondary Bordetella bronchiseptica pneumonia in dogs

A quantitative real time polymerase chain reaction PCR revealed canine distemper virus presence in peripheral blood samples from asymptomatic and non vaccinated dogs. Gross pulmonary alterations were similar with little individual variation.


The virus contributed to the near-extinction of the black-footed ferret. Cycle threshold values were determined by automated threshold analysis of ABI Prism software v. Archived copy as title All articles lacking reliable references Articles lacking reliable references from December Wikipedia articles needing page number citations from December All pages needing factual verification Wikipedia articles needing factual verification from December Articles with ‘species’ microformats All articles with unsourced statements Articles with unsourced statements from December Commons category link is on Wikidata Wikipedia articles with BNF identifiers Wikipedia articles with LCCN identifiers Wikipedia articles with SUDOC identifiers.

The quantitative real time PCR tech-nique has been used for CDV detection and quantification in blood samples, conjunctive swabs, urine, and tissues in dogs showing clinical signs of disease, and also in infected VERO cells Elia et al. These strays act as a reservoir for the virus, spreading it throughout the surrounding area, including urban areas. Distemper is caused by a single-stranded RNA virus of the family Paramyxoviridaewhich is a close relative of the viruses that cause measles in humans and rinderpest in animals.

Histopathological evaluation revealed severe purulent broncopneumonia.

Distmper from eleven domestic dogs with no signs of canine distemper and not vaccinated at the cnaina of collection were used. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

The H gene protein is used for attachment to receptors on the cell in the first step of infection, and an adequate host immune response against the H protein may prevent CDV infection von Messling et al. This is a result of the virus killing the cells responsible for manufacturing the tooth enamel. A quantitative real time PCR reaction in asymptomatic dog’s secretions would be helpful to answer this question.

The virus initially replicates in the lymphatic tissue of the respiratory tract. Transient fever reaches a peak 3 to 6 days after infection and is associated with the initial virus spread in the body.

A quantitative real time PCR assay using blood samples to detect asymptomatic infection in dogs would help to detect the virus during viremia, before it reaches idstemper cells and be detectable in animal secretions and excretions.


This would include cznina larger sample and different seasonal sampling. Puppies experience the highest distfmper rate, where complications such as pneumonia and encephalitis are more common.

Less commonly, they may lead to blindness and paralysis. The origin of the word “distemper” is from the Middle English distemperenmeaning to upset the balance of the humors, which is from the Old French destemprermeaning to disturb, which is from the Vulgar Latin distemperare: Canine distemper virus induces apoptosis through caspase-3 and -8 activation in distejper cells.

Wikimedia Commons has media related to Canine distemper.

Both dogs were necropsied shortly after death. Specimens of infected pulmonary tissue were collected asseptically and sent for bacterial evaluation. In these cases, marked accumulation of degenerated neutrophils in bronchial and alveolar air spaces, necrosis of bronchiolar and bronchial epithelial cells, small isolated foci of severe necrosis, scattered haemorrhagic areas, and intralesional bacteria were observed.

However, the disease continues to spread among unvaccinated populations, such as those in animal shelters and pet stores. Examples include administering fluids, electrolyte solutions, analgesics, anticonvulsants, broad-spectrum antibiotics, antipyretics, parenteral nutrition, and nursing care. Vetstreet does not provide medical advice, diagnosis, or treatment. Nervous tissues were unaltered at necropsy.

Canine distemper virus detection in asymptomatic and non vaccinated dogs

Have a point of view to share? Plasma phase viremia in canine distemper virus infection.

They also allowed the construction of a dilution curve for the absolute quantification of the samples tested in real time PCR. Jorge Guerrero 6 de noviembre de Hence, the use of gel-based PCR is useful but not enough to detect CDV in asymptomatic animals, because it is a qualitative and not a quantitative technique. Despite the effectiveness of the vaccination, outbreaks of this disease continue to occur nationally.