The effects of the aqueous crude extract (5%) of Eugenia punicifolia on cholinergic nicotinic neurotransmission were investigated. Actions of. Eugenia punicifolia (Kunth) DC (Myrtaceae), popularly known as pedra-ume-caĆ”, pedra-ume, murta, or muta, is a shrub found mainly in the. Figure 16 Body weight evolution in rats with acetic acid-induced gastric ulcers treated with oral administration of vehicle, lansoprazole.

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Epidermal growth factor expression in the gastric mucosa of rats with acetic acid-induced gastric ulcers treated with oral administration of vehicle, lansoprazole, or hydroalcoholic extract from the leaves of Eugenia punicifolia for 14 d. Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males Wound formation and subsequent healing represent dynamic processes of extracellular matrix remodeling, mainly influenced by MMP-2 and MMP The material was observed under an optical microscope, and the estrous cycle phase was determined by cytology[ 18 – sugenia ].

The increased expression of EGF in rats treated with LZ may reflect the ongoing healing of gastric ulcers in these animals, with intact females having progressed further pumicifolia males and Pjnicifolia females.

The pattern of metalloproteinase expression by corneal fibroblasts is altered by passage in cell culture. Ulcer healing requires filling of the defect with cells and connective tissue, which is accomplished by cell migration, proliferation mediated by EGFapoptosis mediated by caspases and Bcl-2angiogenesis mediated by VEGF and remodeling mediated by MMPspnuicifolia leading to scar formation.

B Grade C Good: Punicjfolia Eugenia punicifolia var. The bands representative of the gelatinase activity of matrix metalloproteinase MMP -2 and MMP-9 were analyzed in terms of the integrated optical density IOD of the bands.


Therefore, alternative therapies for gastric ulcers are desirable[ 9 ]. Additionally, ovariectomized OVZ females were included. Zymography-based evaluation of matrix remodeling activity The complete protocol for gelatin zymography was previously described by Justulin et al[ 27 ]. Berg Eugenia platyclada O.

Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats

Group allocation was performed according to sex male vs femalehormonal status in females intact vs OVZand treatment negative control vs positive control vs HEEP. The integrity of the gastric mucosa is highly dependent on the continuous generation of prostaglandins by COX-1 and COX-2[ 46 ]. Additionally, ovariectomized OVZ females were included.

We investigated the effects of extracts from the leaves of E. Berg Eugenia suffruticosa var. Berg Eugenia triphylla O.

The in vivo experiments used male g and female g Wistar albino rats obtained from the breeding facility of the State University of Campinas Multidisciplinary Center for Biological Research.

The anti-ulcerogenic activity of estrogen was previously explained by its stimulating effect on parietal cell activity and maintenance of mucus integrity[ 34 ]. University of California Press. Notably, HEEP promoted the expression of vascular ounicifolia growth eugenua intact vs ovariectomized females and decreased the expression of Caspase-8 and Bcl-2 intact female vs male or ovariectomized female. Endothelin-1, an ulcer inducer, promotes gastric ulcer healing via mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors.

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The plates were eugenix after 24 h and 48 h of incubation to assess the closure of the scratch wounds. Article-Type of This Article.

Gastric ulcers, which result from an imbalance between the protective and aggressive agents at the surface of the gastric mucosa, is a chronic disease that affects millions around the world and has high relapse rates[ 12 ].


Matrix remodeling in HEEP-mediated healing of gastric ulcers. Punicfiolia 1 Organ weights following the d treatment of male rats with acetic acid-induced gastric ulcers with lansoprazole and hydroalcoholic extract from the leaves of Eugenia punicifolia.

Observations on normal healing.

Thereafter, the solution was filtered, and the residue was extracted twice more. The species naturally occurs in a variety of environments and is likely not too picky about soil requirements.

Eugenia punicifolia – Wikipedia

Acmena smithii Eugenia smithii Lilly Pilly. The plates were evaluated after 24 h and 48 h of incubation to assess the closure of the scratch wounds. Both types can be used for landscaping projects. Berg Eugenia romana var. Eugenia klotzschiana Brazilian Pear. Protein expression levels in HEEP-mediated healing of gastric ulcers To determine the protein expression profiles associated with HEEP-mediated healing of gastric ulcers, we examined the western blotting gels for several important contributors to cell growth and cell death.

The proliferation ability of fibroblasts eugwnia to HEEP was assessed using the scratch-wound assay, according to a protocol previously described by Balekar et al[ 24 ], with a few modifications. The euenia animals included in the study 30 males, 30 intact females, 24 ovariectomized females were divided into nine groups with individuals each. Berg Eugenia fruticulosa DC. Current treatment strategies for gastric ulcers involve the use of anti-secretory drugs, including antagonists of histamine receptor type 2 e.

In this rat study involving males, intact cycling females, and ovariectomized females, gastric ulcers were induced using acetic acid.