Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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XGC may be difficult to distinguish clinically from acute or chronic cholecystitis; radiologically, it is difficult to distinguish from gallbladder cancer.

The precursor lesions of invasive gallbladder carcinoma. Ceroidlike histiocytic granulomas of gallbladder. Grossly the lesions are usually soft, yellow to brown, and measure up to 2.

There were multiple black pigmented gallstones ranging from 0. Also, there appears to be a positive association between the two lesions. Pathology of Xanthogranulomatous Cholecystitis.

A Case of Xanthogranulomatous Cholecystitis

There were also multiple black pigmented gallstones ranging from 0. Sign up for our Email Newsletters. Cell composition and a hhistopathology pathogenetic role of cell-mediated immunity.


Xanthogranulomatous cholecystitis associated with carcinoma of gallbladder. Coagulation profiles were PT Clinico-pathological study of xanthogranulomatous cholecystitis. The pathogenesis of XGC is uncertain, but histologic evidence of chronic inflammation is generally seen and gallstones are present in a large majority of cases. Magnetic resonance imaging MRI demonstrated diffuse wall thickening of chooecystitis gallbladder by viewing high signal foci with signal void lesions. Xanthogranulomatous cholecystitis is a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma.

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XGC is characterized grossly by irregular wall thickening of the gallbladder associated with the formation of yellowish nodules. A clinical and pathologic study of twelve cases. Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: The lesions appear to result from ruptured Rokitansky-Aschoff sinuses with intramural extravasation of bile and subsequent xanthogranulomatous reaction. It xanthogranulomatois been suggested that XGC is initiated by a chronic inflammation and obstruction.

Computed tomogram CT revealed a well-marginated, uniform, marked wall thickening of the gallbladder with multiseptate enhancement Fig. Previous reports have suggested that the important process is the extravasation of bile into the gallbladder wall, either from ruptured Rokitansky-Aschoff sinuses or focal mucosal ulceration 25.


The pathologic findings showed the collection of foamy histiocytes containing abundant lipid in the cytoplasm and admixed lymphoid cells.

Xanthogranulomatous cholecystitis – Libre Pathology

Rebound tenderness or hepatosplenomegaly was not found. Home About Us Advertise Amazon.

A Case of Xanthogranulomatous Cholecystitis. J Clin Pathol 40 4: After factor VIII replacement, exploration was done. Gastroenterol Res Pract A clinicopathological study of 20 cases and review of the literature. This page was last modified on 30 Mayat Images hosted on other servers: This unusual entity is characterized morphologically by a broad if of xanthogranulomatous changes seen from a small limited focus within yellow nodule in the histopzthology wall, to diffuse involvement of the entire gallbladder with extension of the fibrosis into surrounding tissues.

Surgical procedures and histopathologic findings for patients with xanthogranulomatous cholecystitis.: